Effect of Picrorrhizae Rhizoma Aqueous Extracts on Paw Chronic Inflammation In Mice
نویسندگان
چکیده
⋅Received:25 May 2015 ⋅Revised:18 June 2015 ⋅Accepted:19 June 2015 ⋅Correspondence to:Ji-Ha Park Department of Herbology, College of Oriental Medicine, Daegu Hanny University 1 Haanydaero, Gyeongsan-si, Gyeongsanbuk-Do, Korea Tel:+82-53-819-1874, Fax:+82-53-819-1850, E-mail:[email protected] Objectives: The purpose of this study was to examine the efficacy of Picrorrhizae Rhizoma (PR) aqueous extracts on the formalin-induced paw chronic inflammation in mice. Methods: PR extracts (500, 250 and 125mg/kg) or distilled water (DW) were orally administered once a day for 10 days to formalin-injected chronic inflammatory mice. The paw thicknesses and volumes were measured daily and the paw wet-weight and histological profiles were conducted at termination with paw tumor necrosis factor (TNF)-α contents measurement. The anti-inflammatory effects of PR extracts were compared with dexamethasone. Results: In DW treated control group, the paw thickness, paw wet-weights and paw TNF-α contents were markedly increased. Severe chronic inflammation signs such as severe fibrosis, the formation of necrotic debris, and infiltration of inflammatory cells were detected in histopathological observations. However, these formalin-induced changes were dramatically decreased by treatment of dexamethasone and all three different dosages of PR extracts. The anti-inflammatory effects of PR at highest dose were slighter than that of dexamethasone, but it did not show any harmful effects on the body weight contrary to dexamethasone. Conclusion: These results suggest that PR extracts have safe and favorable effects on formalin-induced chronic inflammation.
منابع مشابه
Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice
BACKGROUND Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-inflammatory activity of saffron extracts in mice. RESULTS We used aqueous and ethanolic maceration extracts of Crocus sativus L. stigma and petals. Antinociceptive activity was examined using the hot plate and writhing tests. The effect ...
متن کاملAntinociceptive and Anti-inflammatory Effects of Pistacia vera Leaf Extract in Mice
Pistacia vera L., a member of Anacardiaceae family, has been used for sedation and analgesia in traditional medicine. In this study, the antinociceptive and anti-inflammatory effects as well as acute toxicity of the aqueous and ethanolic extracts of P. vera leaves were investigated in mice. The antinociceptive activity was studied using hot plate and writhing tests. The effect of the extracts a...
متن کاملEffect of DHU001, a Polyherbal Formula on Formalin-induced Paw Chronic Inflammation of Mice
The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on the formalin-induced paw chronic inflammation in mice after oral administration. Mice were subaponeurotically injected in the left hind paw with 0.02 ml of 3.75% formalin, then subjected to 500, 250 and 125 mg/kg of DHU001 oral administration, once a day for 10 ...
متن کاملThe effect of aqueous extract of Coriandrium sativum seed on acute and chronic pain in formalin test in mice
Previous investigations have shown that Coriandrium sativum (CS) modulates pain in both animals and human. The aim of this research was to assess the role of CS on acute and chronic pain in formalin test in mice. In this study, male albino mice (n=35) in 5 groups (25-30 g) were used. CS (100, and 200 mg/kg) and saline were injected 30 min before formalin test. Indexes of signs were licking and ...
متن کاملAntinociceptive and Anti-inflammatory Effects of Pistacia vera Leaf Extract in Mice
Pistacia vera L., a member of Anacardiaceae family, has been used for sedation and analgesia in traditional medicine. In this study, the antinociceptive and anti-inflammatory effects as well as acute toxicity of the aqueous and ethanolic extracts of P. vera leaves were investigated in mice. The antinociceptive activity was studied using hot plate and writhing tests. The effect of the extracts a...
متن کامل